Norbert Weissmann Selected Research

Monocrotaline

2/2021	Therapeutic Potential of Regorafenib-A Multikinase Inhibitor in Pulmonary Hypertension.
1/2021	Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2.
1/2019	Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension.
1/2018	ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension.
7/2017	Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.
3/2016	Nestin-expressing vascular wall cells drive development of pulmonary hypertension.
9/2014	Endothelin-1 driven proliferation of pulmonary arterial smooth muscle cells is c-fos dependent.
7/2014	Lysyl oxidases play a causal role in vascular remodeling in clinical and experimental pulmonary arterial hypertension.
12/2013	Function of NADPH oxidase 1 in pulmonary arterial smooth muscle cells after monocrotaline-induced pulmonary vascular remodeling.
9/2013	Mitochondrial hyperpolarization in pulmonary vascular remodeling. Mitochondrial uncoupling protein deficiency as disease model.

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Norbert Weissmann Research Topics

Disease

85	Pulmonary Hypertension 01/2022 - 01/2002
78	Hypoxia (Hypoxemia) 01/2022 - 01/2002
37	Vascular Remodeling 02/2021 - 05/2003
26	Pulmonary Arterial Hypertension 01/2022 - 04/2002
18	Inflammation (Inflammations) 10/2021 - 02/2007
18	Fibrosis (Cirrhosis) 01/2019 - 09/2002
16	Hypertrophy 01/2021 - 08/2007
15	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 03/2010
14	Familial Primary Pulmonary Hypertension 01/2022 - 07/2005
12	Emphysema 01/2022 - 03/2010
11	Cardiomegaly (Heart Hypertrophy) 01/2019 - 01/2004
10	Pulmonary Fibrosis (Fibrosing Alveolitis) 03/2022 - 12/2003
8	Right Ventricular Hypertrophy 01/2021 - 01/2010
8	Pneumonia (Pneumonitis) 01/2019 - 08/2002
7	Lung Diseases (Lung Disease) 01/2022 - 11/2009
6	Idiopathic Pulmonary Fibrosis 01/2022 - 10/2010
6	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 04/2006
6	Sepsis (Septicemia) 06/2020 - 04/2006
5	Heart Failure 11/2020 - 01/2015
5	Ischemia 10/2020 - 03/2009
5	Body Weight (Weight, Body) 12/2018 - 12/2003
4	Pulmonary Emphysema 01/2019 - 03/2010
4	Acute Lung Injury 01/2018 - 02/2007
4	Pneumococcal Pneumonia 01/2018 - 04/2014
4	Lung Injury 04/2014 - 05/2008
4	Neoplasms (Cancer) 10/2011 - 03/2004
3	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2022 - 12/2003
3	Heart Diseases (Heart Disease) 01/2022 - 08/2016
3	Neointima 01/2021 - 01/2012
3	Edema (Dropsy) 10/2020 - 05/2008
3	Atherosclerosis 10/2020 - 12/2015
3	Ventricular Remodeling 03/2018 - 02/2012
3	Vascular Diseases (Vascular Disease) 03/2017 - 10/2005
3	Acidosis 01/2012 - 04/2006
3	Pulmonary Heart Disease (Cor Pulmonale) 10/2005 - 01/2004

Drug/Important Bio-Agent (IBA)

30	MonocrotalineIBA 02/2021 - 01/2004
23	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2004
16	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 12/2003
15	SmokeIBA 01/2022 - 10/2011
15	NADPH Oxidases (NAD(P)H oxidase)IBA 10/2020 - 05/2004
13	Oxygen (Dioxygen)IBA 10/2021 - 05/2003
12	Sildenafil Citrate (Viagra)FDA Link 01/2018 - 04/2002
11	Transcription Factors (Transcription Factor)IBA 01/2022 - 10/2002
11	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 09/2002
11	Iloprost (Ventavis)FDA Link 07/2008 - 04/2002
10	Semaxinib (SU5416)IBA 01/2021 - 09/2008
10	Soluble Guanylyl CyclaseIBA 01/2018 - 01/2006
10	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2015 - 11/2002
9	Superoxides (Superoxide)IBA 01/2020 - 12/2003
8	Bleomycin (Blenoxane)FDA LinkGeneric 03/2022 - 12/2003
7	CytokinesIBA 01/2022 - 03/2006
7	Messenger RNA (mRNA)IBA 10/2015 - 05/2004
7	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidIBA 02/2011 - 12/2003
6	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022 - 04/2011
6	riociguatIBA 01/2019 - 03/2010
6	Phosphodiesterase 5 InhibitorsIBA 01/2018 - 01/2004
6	Small Interfering RNA (siRNA)IBA 10/2015 - 04/2011
6	Imatinib Mesylate (Gleevec)FDA Link 01/2013 - 10/2005
6	ThromboxanesIBA 02/2011 - 12/2003
6	Vasoconstrictor AgentsIBA 01/2010 - 07/2005
5	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2022 - 01/2008
5	Protein Isoforms (Isoforms)IBA 11/2020 - 04/2006
5	AntioxidantsIBA 02/2018 - 04/2006
5	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 03/2016 - 10/2005
5	CollagenIBA 01/2015 - 12/2003
5	ProstaglandinsIBA 07/2008 - 07/2003
4	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2022 - 11/2009
4	Vasodilator Agents (Vasodilators)IBA 09/2021 - 04/2002
4	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2021 - 05/2011
4	Tamoxifen FDA LinkGeneric 01/2021 - 04/2012
4	Biomarkers (Surrogate Marker)IBA 06/2020 - 11/2013
4	Ion Channels (Ion Channel)IBA 01/2020 - 02/2014
4	Nitric Oxide Synthase (NO Synthase)IBA 01/2019 - 04/2006
4	LipidsIBA 01/2019 - 02/2007
4	Matrix Metalloproteinases (MMPs)IBA 01/2019 - 09/2013
4	Guanosine Monophosphate (5' Guanylic Acid)IBA 01/2019 - 01/2004
4	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 12/2018 - 09/2008
4	TRPC6 Cation ChannelIBA 01/2017 - 12/2006
4	Pharmaceutical PreparationsIBA 11/2013 - 03/2004
4	Platelet-Derived Growth FactorIBA 06/2012 - 04/2011
4	Epoprostenol (Prostacyclin)FDA LinkGeneric 10/2007 - 04/2002
3	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 03/2022 - 05/2010
3	EnzymesIBA 01/2022 - 01/2008
3	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2021 - 08/2017
3	Tadalafil (Cialis)FDA Link 10/2020 - 10/2004
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2018 - 07/2014
3	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 01/2018 - 10/2004
3	EndotoxinsIBA 01/2017 - 08/2002
3	Chymases (Chymase)IBA 10/2015 - 01/2013
3	AdrenomedullinIBA 04/2014 - 03/2006
3	Becaplermin (PDGF-BB)FDA Link 01/2013 - 04/2011
3	Phosphotransferases (Kinase)IBA 06/2012 - 11/2008
3	Tyrosine (L-Tyrosine)FDA Link 04/2011 - 01/2008
3	diethylstilbestrol monophosphate (PDES)IBA 04/2011 - 01/2010
3	tolafentrineIBA 03/2011 - 04/2004
3	Phosphodiesterase InhibitorsIBA 01/2010 - 01/2005
3	Arginine (L-Arginine)FDA Link 11/2009 - 10/2006
2	Type 6 Cyclic Nucleotide PhosphodiesterasesIBA 01/2022 - 10/2010

Therapy/Procedure

24	Therapeutics 10/2021 - 04/2002
5	Lasers (Laser) 01/2021 - 09/2005